1218949-05-3Relevant articles and documents
In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes
Shaheen, Farkhanda,Badshah, Amin,Gielen, Marcel,Croce, Gianluca,Florke, Ulrich,Vos, Dick de,Ali, Saqib
, p. 315 - 322 (2010/04/27)
Metallacyclic palladium(II) complexes [Pd(L)(R3P)Cl], L = TIQDTC (1,2,3,4-tetrahydroisoquinolinedithiocarbamate), 4MpipDTC (4-methylpipradinedithiocarbamate), MPizDTC (N-methylpiperazinedithiocarbamate), R3P = Ph3P, (o-tolyl)3P, Ph2ClP, were synthesized in a 1:1 molar metal-ligand ratio. These complexes were characterized by elemental analyses, FT-IR, multinuclear (1H, 13C and 31P) NMR. The X-ray crystal structures of [Pd(TIQDTC)(Ph3P)Cl] and [Pd(TIQDTC)((o-tolyl)3P)Cl] show a slightly distorted square planar environment around the Pd(II) ion with S-Pd-S and P-Pd-Cl average bond angles of 74.51 and 92.41, respectively. These complexes were screened for cytotoxic, antifungal, anti-inflammatory and antibacterial activity. Some complexes exhibit a significant activity against fungi.