1219694-13-9

Basic information

• Product Name: C₁₈H₁₅F₃O₆
• Synonyms: C₁₈H₁₅F₃O₆
• CAS NO: 1219694-13-9
• Molecular Weight: 384.309
• Mol File: 1219694-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₅F₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₅F₃O₆(1219694-13-9)
• EPA Substance Registry System: C₁₈H₁₅F₃O₆(1219694-13-9)

Safety Data

• Hazardous Substances Data: 1219694-13-9(Hazardous Substances Data)

Upstream product

• 4405-18-9 5-[1,3]dioxolan-2-yl-benzo[1,3]dioxole 
• 659-28-9 p-trifluoromethoxybenzaldehyde 

Relevant articles and documents

Synthesis and the biological evaluation of arylnaphthalene lignans as anti-hepatitis B virus agents

We have previously shown that helioxanthin can suppress human hepatitis B virus gene expression. A series of helioxanthin analogues were synthesized and evaluated for their anti-hepatitis B virus activity. Modifications at the lactone rings and methylenedioxy unit of helioxanthin can modulate the antiviral activity. Among them, compound 32 is the most effective anti-HBV agent. Compound 32 can suppress the secretion of viral surface antigen and e antigen in HepA2 cells with EC50 values of 0.06 and 0.14 μM, respectively. Compound 32 not only inhibited HBV DNA with wild-type and lamivudine-resistant strain but also suppressed HBV mRNA, core protein and viral promoters. In this study, a full account of the preparation, structure-activity relationships of helioxanthin analogues, and the possible mechanism of anti-HBV activity of this class of compounds are presented. This type of compounds possesses unique mode of action differing from existing therapeutic drugs. They are potentially new anti-HBV agents.