1219794-57-6

Basic information

• Product Name: Tolbutamide-d9
• Synonyms: 1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;Artosin-d9;Artozin-d9;Mobenol-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;Tolylsulfonylbutylurea-d9
• CAS NO: 1219794-57-6
• Molecular Formula: C12H9D9N2O3S
• Molecular Weight: 279.403376002
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 1219794-57-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 108-111°C
• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: Tolbutamide-d9(CAS DataBase Reference)
• NIST Chemistry Reference: Tolbutamide-d9(1219794-57-6)
• EPA Substance Registry System: Tolbutamide-d9(1219794-57-6)

Safety Data

• Hazardous Substances Data: 1219794-57-6(Hazardous Substances Data)

Usage

Description

Tolbutamide-d9 is a labeled version of Tolbutamide, an antidiabetic compound. It is a white solid intended for use as an internal standard for the quantification of tolbutamide by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry (MS). Tolbutamide-d9 serves as an inhibitor of the sulfonylurea receptor 1 (SUR1) linked to the ATP-sensitive potassium channel Kir6.2, with a high degree of selectivity for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels. It plays a crucial role in increasing glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets, and in reducing blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ).

Uses

Used in Pharmaceutical Industry:
Tolbutamide-d9 is used as an internal standard for the quantification of tolbutamide in pharmaceutical research and development. It aids in the accurate measurement and analysis of tolbutamide levels, which is essential for the development and quality control of antidiabetic medications.
Used in Veterinary Medicine:
Tolbutamide-d9 is used as a hypoglycemic agent in veterinary medicine. It helps in the treatment of type 2 diabetes in animals by regulating blood glucose levels and enhancing insulin secretion.
Used in Research and Development:
Tolbutamide-d9 is utilized in research and development for the study of diabetes and its underlying mechanisms. It serves as a valuable tool for understanding the interactions between sulfonylurea receptors and ATP-sensitive potassium channels, as well as their role in glucose homeostasis and insulin secretion.
Used in Quality Control and Validation:
Tolbutamide-d9 is employed in the quality control and validation processes of pharmaceutical manufacturing. It ensures the accuracy and reliability of tolbutamide measurements, which is vital for the safety and efficacy of antidiabetic medications.
Used in Drug Formulation Development:
Tolbutamide-d9 is used in the development of drug formulations containing tolbutamide. It helps in optimizing the formulation's effectiveness and safety profile, ultimately contributing to the successful treatment of type 2 diabetes.