1219807-87-0 Usage
Description
4-Iodo Suberoylanilide HydroxaMic Acid, also known as SAHA, is a hydroxamic acid derivative that exhibits antiproliferative activity in several human cancer cell lines. It functions as an antitumor agent and has potential applications in the field of oncology.
Uses
Used in Oncology:
4-Iodo Suberoylanilide HydroxaMic Acid is used as an antitumor agent for its antiproliferative activity in several human cancer cell lines. It targets and inhibits the activity of histone deacetylases (HDACs), a group of enzymes that play a crucial role in the regulation of gene expression. By inhibiting HDACs, SAHA can induce cell cycle arrest, apoptosis, and differentiation in cancer cells, thereby exhibiting potential therapeutic effects against various types of cancer.
Additionally, SAHA may be used in combination with other chemotherapeutic agents to enhance the overall effectiveness of cancer treatment and overcome drug resistance in certain cancer types. Its potential applications in oncology research and drug development make it a valuable compound for further investigation and clinical trials.
Biological Activity
4-iodo-saha is a hydrophobic derivative of saha, the class i and class ii histone deacetylase (hdac) inhibitor [1].the reversible acetylation of lysine residues in histone plays an important role in transcriptional activation and repression. the regulation of these post-translational modifications is balanced by histone acetyltransferase (hat) and histone deacetylase (hdac) activities. hdacs are also involved in reversible acetylation of non-histone proteins [1].4-iodo-saha is a histone deacetylase (hdac) inhibitor. in skbr3-breast-derived cell line, 4-iodo-saha inhibited cell proliferation with ec50 value of 1.1 μm. in ht29 colon-derived cell line, leukemia-derived u937 tumor cell line, ja16, hl60 and k562 cell lines, 4-iodo-saha inhibited cell proliferation with ec50 values of 0.95, 0.12, 0.24, 0.85 and 1.3 μm, respectively. 4-iodo-saha is 10-fold more potent as an inhibitor of u937 leukemia cell proliferation compared to saha (0.12 μm versus 1.2 μm). in skbr3 cells, 4-iodo-saha reduced acetylated h4 and p21 levels [1].
references
[1]. salmi-smail c, fabre a, dequiedt f, et al. modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. j med chem. 2010 apr 22;53(8):3038-47.
Check Digit Verification of cas no
The CAS Registry Mumber 1219807-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,8,0 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1219807-87:
(9*1)+(8*2)+(7*1)+(6*9)+(5*8)+(4*0)+(3*7)+(2*8)+(1*7)=170
170 % 10 = 0
So 1219807-87-0 is a valid CAS Registry Number.
1219807-87-0Relevant articles and documents
Synthesis and biological effects of small molecule enhancers for improved recombinant protein production in plant cell cultures
Rebelo, Bárbara A.,Santos, Rita B.,Ascenso, Osvaldo S.,Nogueira, Ana Cláudia,Lousa, Diana,Abranches, Rita,Ventura, M. Rita
, (2019/12/24)
Histone deacetylases are involved in chromatin remodelling and thus play a vital role in the epigenetic regulation of gene expression. HDAC inhibitors alter the acetylation status of histone and non-histone proteins to regulate various cellular events suc
