121989-74-0

Basic information

• Product Name: O-benzyl-N-methoxycarbamate
• Synonyms: O-benzyl-N-methoxycarbamate
• CAS NO: 121989-74-0
• Molecular Weight: 181.191
• Mol File: 121989-74-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: O-benzyl-N-methoxycarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: O-benzyl-N-methoxycarbamate(121989-74-0)
• EPA Substance Registry System: O-benzyl-N-methoxycarbamate(121989-74-0)

Safety Data

• Hazardous Substances Data: 121989-74-0(Hazardous Substances Data)

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1235982-77-0 C₁₄H₁₉NO₄ 
• 1172627-12-1 C₁₄H₁₉NO₄ 
• 1172627-13-2 C₁₅H₂₁NO₄ 

Relevant articles and documents

NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME

The present invention includes compositions that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention.

Electrophilic Aromatic Substitution with N-Methoxy-N-acylnitrenium Ions Generated from N-Chloro-N-methoxyamides: Syntheses of Nitrogen Heterocyclic Compounds Bearing a N-Methoxyamide Group

N-Methoxy-N-acylnitrenium ions (II), generated by treatment of N-chloro-N-methoxyamides with silver carbonate in trifluoroacetic acid, react with arenes to give N-aryl-N-methoxyamides in good yields.In the case of the intramolecular cyclization of N-chloro-N-methoxy-2-phenylacetamides, the mode of cyclization is highly dependent on the nature of ortho or para substituent groups.Nitrenium ions II can primarily attack three positions (C-1, C-2, and C-6) of a phenyl ring.Normally II attack C-6.On the other hand, when the ortho position was occupied with a substituent group, II attacked both C-2 and C-6, in the former case followed by a 1,2-substituent migration, which was proved by a deuterium labeling experiment.Especially, when a methoxy group is substituted on ortho or para position, II attack C-1 due to the effect of the electron-releasing methoxy group to give spiro dienone compounds 39.A general discussion of the utility and mechanistic details of these reactions is presented.