122-85-0

Basic information

• Product Name: 4-Acetamidobenzaldehyde
• Synonyms: p-Formylacetanilide;P-ACETYLAMINOBENZALDEHYDE;P-ACETAMINOBENZALDEHYDE;P-ACETAMIDOBENZALDEHYDE;N1-(4-FORMYLPHENYL)ACETAMIDE;N-(4-FORMYL-PHENYL)-ACETAMIDE;AKOS B004036;4-ACETAMIDOBENZALDEHYDE
• CAS NO: 122-85-0
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: 204-579-2
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 122-85-0.mol
• Article Data: 65

Chemical Properties

• Melting Point: 148-153 °C(lit.)
• Boiling Point: 290.25°C (rough estimate)
• Flash Point: 181.8 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.2021 (rough estimate)
• Vapor Pressure: 4.12E-06mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 14?+-.0.70(Predicted)
• Water Solubility: 3.247g/L(25 oC)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-Acetamidobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetamidobenzaldehyde(122-85-0)
• EPA Substance Registry System: 4-Acetamidobenzaldehyde(122-85-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/22
• Safety Statements: 37/39-26-24/25-S24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 122-85-0(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

Purification Methods

Recrystallise it from water. The 4-nitrophenylhydrazone, m 264-265o, crystallises as orange needles from EtOH [Hodgson & Beard J Chem Soc 21 1927, Beilstein 14 H 38, 14 II 25, 14 III 75, 14 IV 71.]

InChI:InChI=1/C9H9NO2/c1-7(12)10-9-4-2-8(6-11)3-5-9/h2-6H,1H3,(H,10,12)

Upstream product

• 556-18-3 4-aminobenzaldehyde 
• 108-24-7 acetic anhydride 
• 25412-53-7 4-(acetamido)benzylamine 
• 16375-88-5 N-(4-hydroxymethylphenyl)acetamide 
• 110853-54-8 (E)-N-[4-[hydroxyiminomethyl]phenyl]acetamide 
• 83810-19-9 2-(4-acetamidophenyl)-1,3-dithiane 
• 71937-13-8 (E)-4-((4-acetamidobenzylidene)amino)benzoic acid 
• 105900-10-5 1,3-dimethyl-2-(p-acetamidophenyl)-1,3-diazolidine 
• 76-05-1 trifluoroacetic acid 
• 64-17-5 ethanol 
• 99-99-0 1-methyl-4-nitrobenzene 
• 556-08-1 p-(acetylamino)benzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 103-84-4 Acetanilid 

Downstream Products

• 67249-02-9 (E)-3-(4-acetylaminophenyl)acrylic acid 
• 42285-10-9 4-(4-acetylamino-thiobenzoyl)-morpholine 
• 106736-68-9 acetic acid-{4-[(4-methyl-piperazinoimino)-methyl]-anilide} 
• 1530-60-5 3-((Ξ)-4-acetylamino-benzylidene)-dihydro-furan-2-one 
• 100871-34-9 acetic acid-[4-([2]pyridylhydrazono-methyl)-anilide] 
• 104742-64-5 acetic acid-[4-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-anilide] 
• 73855-55-7 acetic acid-[4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-anilide] 
• 54-00-2 4-(4-amino-trans-styryl)quinoline 
• 100867-94-5 furan-2-carboxylic acid-(4-acetylamino-benzylidenehydrazide) 
• 96634-03-6 furan-2-carbothioic acid-(4-acetylamino-benzylidenehydrazide) 
• 13115-90-7 1-(4-acetylamino-benzylideneamino)-2-thioxo-imidazolidin-4-one 
• 101092-55-1 nicotinic acid-(4-acetylamino-benzylidenehydrazide) 
• 1158-41-4 isonicotinic acid-(4-acetylamino-benzylidenehydrazide) 
• 109516-25-8 thioisonicotinic acid-(4-acetylamino-benzylidenehydrazide) 

Relevant articles and documents

Oxidation of Substituted Benzyl Alcohols by Pyridinium Fluorochromate: A Kinetic Study

The kinetics of the oxidation of 30 monosubstituted benzyl alcohols to the corresponding benzaldehydes by pyridinium fluorochromate (PFC) have been studied.The reaction is first order with respect to PFC.A Michaelis-Menten type kinetics was observed with respect to the substrate, indicating the formation of a PFC-alcohol complex in the preequilibrium.The formation constants and the rates of disproportionation of the complexes were determined.The oxidation of benzyl alcohol indicated the presence of a substantial primary kinetic isotope effect.The ratesof the decomposition of the complexes of the meta-and para-substituted alcohols were analyzed in terms of Taft's and Swain's dual substituent parameter equations.The meta compounds showed an excellent correlation with Taft's ?I and ?R0 values while the para-substituted compounds correlate with ?1 and ?RBA constants.The rates of the ortho-substituted alcohols correlate with Charton's equation of inductive, resonance, and steric paramaters.The reaction was studied in 19 solvents.The correlation analysis of the solvent effect indicated the greater importance of the cation-solvating power of the solvent.The reaction involves a hydride ion transfer in the rate-determining step.

An aerobic oxidation of alcohols into carbonyl synthons using bipyridyl-cinchona based palladium catalyst

We have reported an aerobic oxidation of primary and secondary alcohols to respective aldehydes and ketones using a bipyridyl-cinchona alkaloid based palladium catalytic system (PdAc-5) using oxygen at moderate pressure. ThePdAc-5catalyst was analysed using SEM, EDAX, and XPS analysis. The above catalytic system is used in experiments for different oxidation systems which include different solvents, additives, and bases which are cheap, robust, non-toxic, and commercially available on the industrial bench. The obtained products are quite appreciable in both yield and selectivity (70-85%). In addition, numerous important studies, such as comparisons with various commercial catalysts, solvent systems, mixture of solvents, and catalyst mole%, were conducted usingPdAc-5. The synthetic strategy of oxidation of alcohol into carbonyl compounds was well established and all the products were analysed using1H NMR,13CNMR and GC-mass analyses.

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2

Pt nanoparticles supported on N doped titanium dioxide/titanium carbide (MXene) heterojunctions were employed as photocatalysts for the tandem reactions between aromatic nitro compounds and carboxylic acids to produce amide products. The 3%Pt/N-TiO2/Ti3C2 heterojunction was prepared by in situ grew TiO2 on Ti3C2 nanosheets and then N doped TiO2 with melamine, Pt nanoparticles with 3.3 nm mean diameter well dispersed on N-TiO2/Ti3C2. 3%Pt/N-TiO2/Ti3C2 had excellent amidation activity and chemoselectivity under visible-light irradiation. The elevated catalytic performance of 3%Pt/N-TiO2/Ti3C2 was owing to the improvement in photogenerated electron and hole separation efficiency through charge short-range directional transmission caused by the intimate contact between the TiO2 and the conductive Ti3C2. This direct hydrogenation along with amidation between nitroaromatics and carboxylic acids own actual merits in the amides produce with no harmful byproducts. In situ DRIFTS spectra verified that the amidation activation with visible light irradiation at 25 °C was much faster than heating.