1220038-66-3 Usage
Derivative of Piperidine
A compound structurally related to the piperidine ring, which is a six-membered nitrogen-containing heterocyclic compound.
Relation to Propoxyphene
Etapropazine is structurally related to the analgesic drug propoxyphene, indicating a similarity in their chemical structures and potential pharmacological effects.
Centrally Acting Muscle Relaxant
Etapropazine is used to reduce muscle tension and spasms by acting on the central nervous system.
Analgesic Effect
The compound provides pain relief, particularly for conditions like muscle spasm, tension headache, and fibromyalgia.
Mechanism of Action
Etapropazine's effects are thought to involve central nervous system depression and direct muscle relaxation, which contribute to its muscle relaxant and analgesic properties.
Clinical Use
Etapropazine has been used in clinical settings for the treatment of various conditions, such as muscle spasms, tension headaches, and fibromyalgia.
Limited Market Availability
Although it has been used clinically in the past, 2-(1-Ethyl-3-piperidinyl)acetic acid is not currently widely marketed, indicating limited availability for use.
Check Digit Verification of cas no
The CAS Registry Mumber 1220038-66-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,0,0,3 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1220038-66:
(9*1)+(8*2)+(7*2)+(6*0)+(5*0)+(4*3)+(3*8)+(2*6)+(1*6)=93
93 % 10 = 3
So 1220038-66-3 is a valid CAS Registry Number.
1220038-66-3Relevant articles and documents
Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists
Puleo, Letizia,Marini, Pietro,Avallone, Roberta,Zanchet, Marco,Bandiera, Silvio,Baroni, Marco,Croci, Tiziano
, p. 5623 - 5636 (2012/10/29)
The ghrelin receptor is a G-protein-coupled receptor (GPCR) widely expressed in the brain, stomach and the intestine. It was firstly identified during studies aimed to find synthetic modulators of growth hormone (GH) secretion. GHSR and its endogenous ligand ghrelin were found to be involved in hunger response. Through food intake regulation, they could affect body weight and adiposity. Thus GHSR antagonists rapidly became an attractive target to treat obesity and feeding disorders. In this study we describe the biological properties of new indolinone derivatives identified as a new, chiral class of ghrelin antagonists. Their synthesis as well as the structure-activity relationship will be discussed herein. The in vitro identified compound 14f was a potent GHSR1a antagonist (IC50 = 7 nM). When tested in vivo, on gastric emptying model, 14f showed an inhibitory intrinsic effect when given alone and it dose dependently inhibited ghrelin stimulation. Compound 14f also reduced food intake stimulated both by fasting condition (high level of endogenous ghrelin) and by icv ghrelin. Moreover this compound improved glucose tolerance in ipGTT test.
