1220356-90-0Relevant articles and documents
Synthesis of deuterium-labelled drugs by hydrogen-deuterium (H-D) exchange using heterogeneous catalysis
Modutlwa, Nkaelang,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
, p. 686 - 692 (2010)
Multi-deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post-synthetically achieved by Pd/C-, Pt/C-, or/and Rh/C-catalyzed hydrogen-deuterium exchange reactions under neutral conditions usin