1220393-43-0Relevant articles and documents
A rapid and practical entry into cis-1,4-aminocyclohexanols
Gallou, Fabrice,Han, Bo,Lu, Jiang,Seeger-Weibel, Manuela,Stoessel, Anne-Florence,Allmendinger, Simon
scheme or table, p. 1419 - 1422 (2010/05/03)
A selective and practical approach for the formation of cis-1,4-aminocyclohexanol was developed. The key transformation involves a one-pot imine formation/ Lewis acid-directed imine reduction and results in a highly selective attack of the reducing agent. This simple and practical method is easily amenable to large-scale synthesis.