1220517-78-1

Basic information

• Product Name: 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine
• CAS NO: 1220517-78-1
• Molecular Weight: 402.864
• Mol File: 1220517-78-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine(1220517-78-1)
• EPA Substance Registry System: 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine(1220517-78-1)

Safety Data

• Hazardous Substances Data: 1220517-78-1(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1220517-77-0 2,4-dichloro-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[3,2-d]pyrimidine 
• 89088-69-7 1-methyl-1H-imidazole-4-amine hydrochloride 
• 63200-54-4 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine 

Relevant articles and documents

Discovery of 1-methyl-1 H-imidazole derivatives as potent Jak2 inhibitors

Structure based design, synthesis, and biological evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clinical candidate AZD1480 (24), optimization of the series led to the discovery of compound 19a, a potent, orally bioavailable Jak2 inhibitor. Compound 19a displayed a high level of cellular activity in hematopoietic cell lines harboring the V617F mutation and in murine BaF3 TEL-Jak2 cells. Compound 19a demonstrated significant tumor growth inhibition in a UKE-1 xenograft model within a well-tolerated dose range.