1221176-99-3Relevant articles and documents
Facile method for the combinatorial synthesis of 2,2-Disubstituted Quinazolin-4(1 H)-one derivatives catalyzed by iodine in ionic liquids
Wang, Xiang-Shan,Yang, Ke,Zhou, Jie,Tu, Shu-Jiang
scheme or table, p. 417 - 421 (2010/09/05)
A mild and facile method for the combinatorial synthesis of quinazolin-4-(1H)-one derivatives, containing simple 2,2-disubstituted quinazolin-4-(1H)-ones, spirocyclic quinazolin-4-(1H)-ones, spiro-heterocyclic quinazolin-4-(1H)-ones, and dispirocyclic quinazolin-4-(1H)-ones, is described, which results in high yields by using ionic liquids as green media. The method involves the reaction of 2-aminobenzamides with various ketones catalyzed by iodine and provides new quinazolin-4-(1H)-one library for biomedical screening.