1221179-02-7

Basic information

• Product Name: C₂₄H₂₆N₂OSi
• Synonyms: C₂₄H₂₆N₂OSi
• CAS NO: 1221179-02-7
• Molecular Weight: 386.569
• Mol File: 1221179-02-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₆N₂OSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₆N₂OSi(1221179-02-7)
• EPA Substance Registry System: C₂₄H₂₆N₂OSi(1221179-02-7)

Safety Data

• Hazardous Substances Data: 1221179-02-7(Hazardous Substances Data)

Upstream product

• 98619-07-9 1-(2-fluoro-4-hydroxyphenyl)ethanone 
• 519158-44-2 1-benzyl-3-methyl-1H-indazol-6-ol 
• 201286-99-9 3-methyl-1H-indazol-6-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1221179-03-8 C₂₉H₃₄N₂O₃Si 
• 1221179-36-7 tert-butyl 6-(2-(dibenzylamino)ethoxy)-3-methylindazole-1-carboxylate 
• 1221179-37-8 tert-butyl 6-(2-(benzylamino)ethoxy)-3-methylindazole-1-carboxylate 
• 1221179-29-8 tert-butyl (R)-6-[2-[N-((2-(3-aminophenyl)-2-((triethylsilyl)oxy)ethyl)-N-(tert-butoxycarbonyl)amino)]ethoxy]-3-methyl-1H-indazole-1-carboxylate 
• 1221179-44-7 (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1221179-38-9 (R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methyl indazole-1-carboxylate 
• 1221179-41-4 (R)-tert-butyl 6-(2-(benzyl(2-(4-chloro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1221179-42-5 (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1221179-43-6 (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1283126-28-2 (R)-tert-butyl 6-(2-((2-(3-(3-aminophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1283126-30-6 (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(3-nitrophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1283126-47-5 (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(4-chloro-3-nitrophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboxylate 
• 1283128-39-1 (R)-tert-butyl 6-(2-(tert-butoxycarbonyl-(2-(3-(2-fluorophenylsulfonamide)phenyl)-2-(triethylsilyloxy)ethyl)amino)ethoxy)-3-methylindazole-1-carboyxlate 

Relevant articles and documents

Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects

Novel indazole derivatives were prepared and evaluated for their biological activity and cardiovascular safety profile as human β3-adrenergic receptor (AR) agonists. Although the initial hit compound 5 exhibited significant β3-AR agonistic activity (EC50 = 21 nM), it also exhibited agonistic activity at the α1A-AR (EC50 = 219 nM, selectivity: α1A/β3 = 10-fold). The major metabolite of 5, which was an oxidative product at the indazole 3-methyl moiety, gave a clue to a strategy for improvement of the selectivity for β3-AR agonistic activity versus α1A-AR agonistic activity. Thus, modification of the 3-substituent of the indazole moiety effectively improved the selectivity to develop compound 11 with potent β3-AR agonistic activity (EC50 = 13 nM) and high selectivity (α1A/β3 = >769-fold). Compound 11 was also inactive toward β1 and β2-ARs and showed dose dependent β3-AR mediated relaxation of marmoset urinary bladder smooth muscle, while it did not obviously affect heart rate or blood pressure (iv, 3 mg/kg) in anesthetized rats.