122128-46-5

Basic information

• Product Name: N-benzyl-N-(2-iodophenyl)-2-methylacrylamide
• Synonyms: N-benzyl-N-(2-iodophenyl)-2-methylacrylamide
• CAS NO: 122128-46-5
• Molecular Weight: 377.225
• Mol File: 122128-46-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-(2-iodophenyl)-2-methylacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-(2-iodophenyl)-2-methylacrylamide(122128-46-5)
• EPA Substance Registry System: N-benzyl-N-(2-iodophenyl)-2-methylacrylamide(122128-46-5)

Safety Data

• Hazardous Substances Data: 122128-46-5(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 108501-85-5 N-(2-iodophenyl)-2-methylacrylamide 
• 620-05-3 iodomethylbenzene 
• 615-43-0 2-iodophenylamine 
• 100-39-0 benzyl bromide 
• 76464-99-8 N-benzyl-2-iodoaniline 
• 920-46-7 Methacryloyl chloride 

Downstream Products

• 34944-04-2 2-(1-benzyl-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetic acid 
• 1454770-03-6 (E)-1-benzyl-3-methyl-3-styrylindolin-2-one 
• 1042150-76-4 (S)-2-(1-benzyl-3-methyl-2-oxoindolin-3-yl)acetonitrile 
• 1042150-80-0 (R)-2-(1-benzyl-3-methyl-2-oxoindolin-3-yl)acetonitrile 

Relevant articles and documents

Microwave-Assisted Domino Palladium Catalysis in Water: A Diverse Synthesis of 3,3′-Disubstituted Heterocyclic Compounds

An environmentally benign microwave-assisted domino [Pd]-catalyzed reaction, for the efficient and diverse synthesis of 3,3′-disubstituted indolines, oxindoles, and dihydrobenzofurans, is presented. Significantly, water served as the sole green solvent and the strategy displayed an excellent functional-group tolerance. Remarkably, the process was also amenable to unmasked functional groups and furnished the products, in very good to almost quantitative yields.

Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide

A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent cou

Nickel-Catalyzed Arylcarbamoylation of Alkenes of N-(o-Iodoaryl)acrylamides with Nitroarenes via Reductive Aminocarbonylation: Facile Synthesis of Carbamoyl-Substituted Oxindoles

Nickel-catalyzed arylcarbamoylation reactions of alkenes of N-(o-haloaryl)acrylamides with CO and nitroarenes via reductive aminocarbonylation to produce carbamoyl-substituted oxindoles with an all-carbon quaternary stereogenic center are presented. Starting with N-(o-haloaryl)acrylamides, simple CO, and inexpensive nitroarenes and using a Ni catalyst, a dinitrogen-based ligand, a Zn reductant, a TMSCl additive, and a base system, this protocol enables the synthesis of various carbamoyl-substituted oxindoles and allows the efficient late-stage derivatization of valuable molecules.

Nickel-catalyzed reductive aryl thiocarbonylation of alkene via thioester group transfer strategy

Herein reported is a nickel-catalyzed reductive aryl thiocarbonylation of alkene via thioester group transfer strategy by using simple and readily available thioesters. In contrast to traditional activation of weaker C(acyl)-S bond, the C(acyl)-C bond of