122136-03-2Relevant articles and documents
CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS
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Paragraph 0712; 0716-0717, (2020/03/29)
The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.
Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation
Hada, Kihito,Suda, Atsushi,Asoh, Kohsuke,Tsukuda, Takuo,Hasegawa, Masami,Sato, Yasuko,Ogawa, Kotaro,Kuramoto, Shino,Aoki, Yuko,Shimma, Nobuo,Ishikawa, Tsutomu,Koyano, Hiroshi
experimental part, p. 1442 - 1460 (2012/04/17)
Proliferation of endothelial cells is critical for angiogenesis. We report orally available, in vivo active antiangiogenic agents which specifically inhibit endothelial cell proliferation. After identifying human umbilical vein endothelial cell (HUVEC) pr
An efficient one-pot synthesis of pyrrolo[4,3,2-ij]isoquinoline derivatives by a consecutive aza-wittig/electrocyclic ring-closure/intramolecular acylation process
Molina,Alajarin,Vidal
, p. 293 - 296 (2007/10/02)
Iminophosphorane, ethyl 5-ethoxycarbonyl-2-methoxy-α-[(triphenylphosphoranylidene)amino]cinn amate (4) reacts with aliphatic and aromatic isocyanates in toluene at 170°C to give directly the corresponding pyrrolo[4,3,2-ij]isoquinolines 8 in moderate yields.
