122179-82-2Relevant articles and documents
A Simple and Economic Synthesis of Monoacylated Alkanediamines by Thermal Transamidation
Zaragoza-Doerwald, Florencio,Kiedrowski, Guenter von
, p. 917 - 918 (2007/10/02)
N-(ω-Aminoalkyl)amides 2 are easily synthesized by heating mixtures of excess α,ω-alkanediamines 1 and primary amides to temperatures between 150 deg C and 200 deg C, at which thermal transamidation occurs.Under the reaction conditions ammonia is released, and 2 is in equilibrium with the alkanediamine 1 and the α,ω-bis(acylamino)alkane 3.Thus, thermal transamidation is a practicable way to overcome the problem of diacylation which appears as an often recognized problem even in the latest literature.