1222174-95-9Relevant articles and documents
Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13
Taylor, Steven J.,Abeywardane, Asitha,Liang, Shuang,Muegge, Ingo,Padyana, Anil K.,Xiong, Zhaoming,Hill-Drzewi, Melissa,Farmer, Bennett,Li, Xiang,Collins, Brandon,Li, John Xiang,Heim-Riether, Alexander,Proudfoot, John,Zhang, Qiang,Goldberg, Daniel,Zuvela-Jelaska, Ljiljana,Zaher, Hani,Li, Jun,Farrow, Neil A.
, p. 8174 - 8187 (2012/01/13)
Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of a pot