122224-36-6Relevant articles and documents
Improved synthesis of biotinol-5′-AMP: Implications for antibacterial discovery
Tieu, William,Polyak, Steven W.,Paparella, Ashleigh S.,Yap, Min Y.,Soares Da Costa, Tatiana P.,Ng, Belinda,Wang, Geqing,Lumb, Richard,Bell, Jan M.,Turnidge, John D.,Wilce, Matthew C. J.,Booker, Grant W.,Abell, Andrew D.
, p. 216 - 220 (2015/03/04)
An improved synthesis of biotinol-5′-AMP, an acyl-AMP mimic of the natural reaction intermediate of biotin protein ligase (BPL), is reported. This compound was shown to be a pan inhibitor of BPLs from a series of clinically important bacteria, particularl
Selective N-acylation and N-alkylation of biotin
Pehere, Ashok D.,Abell, Andrew D.
experimental part, p. 9514 - 9518 (2012/01/06)
Simple and efficient methodology is presented for the selective acylation and alkylation of biotin at its 3′-nitrogen.
Synthesis of the ribosomal P-site substrate CCA-pcb
Zhong, Minghong,Strobel, Scott A.
, p. 55 - 58 (2007/10/03)
(Chemical Equation Presented) CCA-pcb (cytidylyl-(3′5′)- cytidylyl-(3′5′)-3′(2′)-O-(N-(6-D-(+) -biotinoylaminohexanoyl)-L-phenylalanyl)adenosine), a ribosomal P-site substrate, was synthesized by phosphoramidite chemistry in 26 steps with an overall yield