122228-09-5

Basic information

• Product Name: Benzoic acid, 4-[(aminoiminomethyl)amino]-, methyl ester (9CI)
• Synonyms: Benzoic acid, 4-[(aminoiminomethyl)amino]-, methyl ester (9CI)
• CAS NO: 122228-09-5
• Molecular Formula: C₉H₁₁N₃O₂
• Molecular Weight: 193.20254
• Product Categories: AMINOACID
• Mol File: 122228-09-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-[(aminoiminomethyl)amino]-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(aminoiminomethyl)amino]-, methyl ester (9CI)(122228-09-5)
• EPA Substance Registry System: Benzoic acid, 4-[(aminoiminomethyl)amino]-, methyl ester (9CI)(122228-09-5)

Safety Data

• Hazardous Substances Data: 122228-09-5(Hazardous Substances Data)

Upstream product

• 16060-65-4 4-guanidinobenzoic acid 
• 67-56-1 methanol 
• 42823-46-1 4-guanidinobenzoic acid hydrochloride 
• 619-44-3 methyl 4-iodobenzoate 
• 506-93-4 guanidine nitrate 
• 420-04-2 CYANAMID 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 1204526-79-3 C₂₁H₁₉N₅O₃ 
• 1204525-85-8 C₁₉H₁₅N₅O₂ 
• 1291073-05-6 C₂₁H₁₆F₃N₅O₂ 
• 1204526-03-3 C₂₁H₁₉N₅O₃ 
• 1204526-10-2 C₂₀H₁₄F₃N₅O₂ 
• 1204526-15-7 C₁₉H₁₆N₆O₂ 
• 1204526-20-4 C₁₉H₁₆N₆O₂ 
• 1204526-46-4 C₂₀H₁₆ClN₅O₂ 
• 1204526-87-3 C₂₀H₁₆FN₅O₂ 
• 1204527-01-4 C₂₁H₁₆F₃N₅O₃ 
• 1381848-20-9 methyl 4-(3-(4-methoxyphenyl)guanidino)benzoate 

Relevant articles and documents

Iron-promoted sulfur sequestration for the substituent-dependent regioselective synthesis of tetrazoles and guanidines

We have established a facile and versatile synthetic methodology for the construction of tetrazoles and guanidines in the presence of an eco-friendly, inexpensive, easily available iron reagent. Aromatic thioureas with electron-donating substituents produced their respective target products in quantitative yield. In contrast, when electron-withdrawing substituted aromatic thioureas were used, the expected products were obtained in reduced yield. However, the desired products were obtained in good yield at moderate temperature. In addition, mechanistic studies revealed that the synthetic route involved iron-based subsequent reactions of addition and removal of sulfur.

Synthesis of symmetrical and unsymmetrical N, N ′-diaryl guanidines via copper/N-methylglycine-catalyzed arylation of guanidine nitrate

CuI/N-methylglycine-catalyzed coupling reaction of guanidine nitrate with both aryl iodides and bromides takes place at 70-100 °C, affording symmetrical N,N′-diaryl guanidines with good to excellent yields. Unsymmetrical N,N′-diaryl guanidines can be assembled via monoarylation of guanidine nitrate with aryl iodides bearing a strong electron-withdrawing group and subsequent coupling with another aryl iodide.

METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION OR INHIBITING JNK

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