1222436-83-0

Basic information

• Product Name: C₂₈H₄₀N₆O₅
• CAS NO: 1222436-83-0
• Molecular Weight: 540.663
• Mol File: 1222436-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₄₀N₆O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₄₀N₆O₅(1222436-83-0)
• EPA Substance Registry System: C₂₈H₄₀N₆O₅(1222436-83-0)

Safety Data

• Hazardous Substances Data: 1222436-83-0(Hazardous Substances Data)

Upstream product

• 73995-50-3 H-Orn(Z)-OBzl 
• 13734-41-3 t-Boc-L-valine 
• 100-63-0 phenylhydrazine 

Relevant articles and documents

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP

We recently reported the systematic ligand-based rational design and synthesis of monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Expanded structure-activity relationship (SAR) studies around these peptidomimetics led to compounds with significantly improved selectivity (>60-fold) for the BIR2 domain versus the BIR3 domain of XIAP. The potent and highly selective IAP antagonist 8q (ML183) sensitized TRAIL-resistant prostate cancer cells to apoptotic cell death, highlighting the merit of this probe compound as a valuable tool to investigate the biology of XIAP.