122253-01-4Relevant articles and documents
PYRIDINE ANCHORS FOR HMG-COA REDUCTASE INHIBITORS
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, (2008/06/13)
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the e
Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids
Beck, G.,Kesseler, K.,Baader, E.,Bartmann, W.,Bergmann, A.,et al.
, p. 52 - 60 (2007/10/02)
Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)