1222707-51-8

Basic information

• Product Name: C₃₂H₄₁N₅O₅
• CAS NO: 1222707-51-8
• Molecular Weight: 575.708
• Mol File: 1222707-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₂H₄₁N₅O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₂H₄₁N₅O₅(1222707-51-8)
• EPA Substance Registry System: C₃₂H₄₁N₅O₅(1222707-51-8)

Safety Data

• Hazardous Substances Data: 1222707-51-8(Hazardous Substances Data)

Upstream product

• 134-32-7 1-amino-naphthalene 
• 13734-41-3 t-Boc-L-valine 
• 73995-50-3 H-Orn(Z)-OBzl 

Relevant articles and documents

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP

We recently reported the systematic ligand-based rational design and synthesis of monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Expanded structure-activity relationship (SAR) studies around these peptidomimetics led to compounds with significantly improved selectivity (>60-fold) for the BIR2 domain versus the BIR3 domain of XIAP. The potent and highly selective IAP antagonist 8q (ML183) sensitized TRAIL-resistant prostate cancer cells to apoptotic cell death, highlighting the merit of this probe compound as a valuable tool to investigate the biology of XIAP.