122281-18-9

Basic information

• Product Name: 5-[(2-Bromo-1-oxo)propyl]-1,3-dihydro-3,3,7-trimethyl-2H-indol-2-one
• CAS NO: 122281-18-9
• Molecular Weight: 310.191
• Mol File: 122281-18-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[(2-Bromo-1-oxo)propyl]-1,3-dihydro-3,3,7-trimethyl-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2-Bromo-1-oxo)propyl]-1,3-dihydro-3,3,7-trimethyl-2H-indol-2-one(122281-18-9)
• EPA Substance Registry System: 5-[(2-Bromo-1-oxo)propyl]-1,3-dihydro-3,3,7-trimethyl-2H-indol-2-one(122281-18-9)

Safety Data

• Hazardous Substances Data: 122281-18-9(Hazardous Substances Data)

Upstream product

• 19501-89-4 1,3-dihydro-3,3,7-trimethyl-2H-indol-2-one 
• 563-76-8 α-bromopropionyl bromide 

Relevant articles and documents

A Novel Class of Cardiotonic Agents: Synthesis and Biological Evaluation of 5-Substituted 3,6-Dihydrothiadiazin-2-ones with Cyclic AMP Phosphodiesterase Inhibiting and Myofibrillar Calcium Sensitizing Properties

As part of a search for new cardiotonic agents significantly sensitising the myocardial contractile proteins to calcium, together with cardiac cyclic AMP-PDE inhibitory activity, we have discovered that novel 5-substituted 3,6-dihydrothiadiazin-2-ones may fulfill both properties.The sensitising effect of the contractile proteins to calcium, assessed by the shift in the calcium sensitivity of canine cardiac myofibrillar magnesium-dependent ATPase, is determined by steric and electronic requirements.The requirements for phosphodiesterase inhibition, especially that of a near-planar arrangement for the phenyl and thiadiazin-2-one ring are consistent with those already described for analogous pyridazinones.The synthesis and structure-activity relationships are discussed.