1222999-45-2

Basic information

• Product Name: C₃₆H₂₃F₃N₄O₂
• CAS NO: 1222999-45-2
• Molecular Weight: 600.599
• Mol File: 1222999-45-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₆H₂₃F₃N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₂₃F₃N₄O₂(1222999-45-2)
• EPA Substance Registry System: C₃₆H₂₃F₃N₄O₂(1222999-45-2)

Safety Data

• Hazardous Substances Data: 1222999-45-2(Hazardous Substances Data)

Upstream product

• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 21168-41-2 4,6-dichloroquinoline-3-carboxylic acid,ethyl ester 
• 586-76-5 4-Bromobenzoic acid 
• 1314568-34-7 C₁₇H₁₁BrClF₃N₂O 
• 191162-39-7 quinolin-3-ylboronic acid 
• 1314568-33-6 C₁₉H₁₃BrClF₃N₂O₂ 
• 214360-57-3 N-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzamide 
• 1314568-35-8 C₁₉H₉BrClF₃N₂O 

Relevant articles and documents

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

Starting from small molecule mTOR inhibitor Torin1, replacement of the piperazine ring with a phenyl ring resulted in a new series of mTOR inhibitors (as exemplified by 10) that showed superior potency and selectivity for mTOR, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.