122329-02-6 Usage
Description
2-Tetradecyloxynitrobenzene, also known as 1-Nitro-2-(tetradecyloxy)benzene, is an organic compound with the molecular formula C20H31NO3. It is characterized by a nitro group attached to a benzene ring and a tetradecyloxy group, which is a long alkyl chain with 14 carbon atoms. 2-Tetradecyloxynitrobenzene has potential applications in various fields due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
2-Tetradecyloxynitrobenzene is used as a protein tyrosine phosphatase 1B (PTP1B) inhibitor for the development of drugs targeting type 2 diabetes and obesity. PTP1B is an enzyme that negatively regulates insulin signaling, and its inhibition can help improve insulin sensitivity and glucose homeostasis. By acting as a PTP1B inhibitor, 2-Tetradecyloxynitrobenzene can potentially contribute to the treatment of metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 122329-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,3,2 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 122329-02:
(8*1)+(7*2)+(6*2)+(5*3)+(4*2)+(3*9)+(2*0)+(1*2)=86
86 % 10 = 6
So 122329-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H33NO3/c1-2-3-4-5-6-7-8-9-10-11-12-15-18-24-20-17-14-13-16-19(20)21(22)23/h13-14,16-17H,2-12,15,18H2,1H3
122329-02-6Relevant articles and documents
Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors
Tong, Yuan Feng,Zhang, Pei,Chen, Feng,Hao, Ling Hua,Ye, Fei,Tian, Jin Ying,Wu, Song
scheme or table, p. 1415 - 1418 (2011/10/09)
Based on the fact that petroselinic acid showed good inhibitory activity (IC50=6.99μmol/L) against protein tyrosine phophatase 1B(PTP1B) in vitro, a series of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives were designed and synthesized. The results indicated that most of the derivatives showed more potent activities against PTP1B. Especially, compound 13 had obvious activity with an IC50 of 106nmol/L in vitro.
