1223399-57-2

Basic information

• Product Name: (3R,11bR)-tetrabenazine D-camphorsulfonate
• CAS NO: 1223399-57-2
• Molecular Weight: 549.729
• Mol File: 1223399-57-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,11bR)-tetrabenazine D-camphorsulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,11bR)-tetrabenazine D-camphorsulfonate(1223399-57-2)
• EPA Substance Registry System: (3R,11bR)-tetrabenazine D-camphorsulfonate(1223399-57-2)

Safety Data

• Hazardous Substances Data: 1223399-57-2(Hazardous Substances Data)

Upstream product

• 3144-16-9 (1S)-10-camphorsulfonic acid 
• 718635-93-9 tetrabenazine 

Downstream Products

• 1026016-83-0 ((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one) 

Relevant articles and documents

Preparation and characterization of tetrabenazine enantiomers against vesicular monoamine transporter 2

As a clinical medication for the treatment of hyperkinetic movement disorders, in conditions such as Huntington's disease, tetrabenazine (TBZ) has always been used in its racemic form. To establish whether or not its beneficial therapeutic actions are enantiospecific, a practical total synthetic route was developed to yield each enantiomeric form to allow their chemical and pharmacological characterization. We briefly summarize the total synthesis of TBZ and report a detailed procedure for resolution of TBZ into its enantiomers, (+)-TBZ and (-)-TBZ. This allowed determination of the optical rotation and absolute configurations of each TBZ enantiomer, based on X-ray crystallographic analysis, together with characterization of their inhibitory action at the vesicular monoamine transporter 2, where (+)-TBZ proved 3-fold more active than (-)-TBZ.