122410-19-9Relevant articles and documents
Asymmetric syntheses of 8-oxabicyclo[3,2,1]octanes: A cationic cascade cyclization
Li, Bin,Zhao, Yu-Jun,Lai, Yin-Chang,Loh, Teck-Peng
supporting information; experimental part, p. 8041 - 8045 (2012/09/05)
High octane: A novel and practical syntheses of 8-oxabicyclo[3.2.1]octanes using a cationic cascade cyclization reaction has been developed (see scheme; TIPS=triisopropylsilyl). The diastereomer of the cyclization product isolated depends upon whether the acetal or aldehyde substrate is used. Copyright
Enantioselective Cationic Polyene Cyclization vs Enantioselective Intramolecular Carbonyl-Ene Reaction
Zhao, Yu-Jun,Li, Bin,Tan, Li-Jun Serena,Shen, Zhi-Liang,Loh, Teck-Peng
supporting information; scheme or table, p. 10242 - 10244 (2010/09/07)
This paper describes highly efficient catalytic enantioselective cationic polyene cyclization and catalytic enantioselective intramolecular carbonyl-ene reaction in good to high yields with high enantioselectivities. The intimate relationship and mechanistic differences between the two enantioselective reactions were studied in detail. In addition, the cyclization products are versatile and useful building blocks for natural products and pharmaceuticals syntheses.