1224597-96-9

Basic information

• Product Name: 4-(3-([bis(dimethylamino)phosphoryl]oxy)pyridin-4-yl)phenyl trifluoromethanesulfonate
• Synonyms: 4-(3-([bis(dimethylamino)phosphoryl]oxy)pyridin-4-yl)phenyl trifluoromethanesulfonate
• CAS NO: 1224597-96-9
• Molecular Weight: 453.379
• Mol File: 1224597-96-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-([bis(dimethylamino)phosphoryl]oxy)pyridin-4-yl)phenyl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-([bis(dimethylamino)phosphoryl]oxy)pyridin-4-yl)phenyl trifluoromethanesulfonate(1224597-96-9)
• EPA Substance Registry System: 4-(3-([bis(dimethylamino)phosphoryl]oxy)pyridin-4-yl)phenyl trifluoromethanesulfonate(1224597-96-9)

Safety Data

• Hazardous Substances Data: 1224597-96-9(Hazardous Substances Data)

Upstream product

• 1224597-88-9 pyridin-3-yl N,N,N',N'-tetramethyldiamidophosphate 
• 109586-39-2 4-iodophenyl trifluoromethanesulfonate 

Relevant articles and documents

Phosphorodiamidate-directed metalation of N -heterocycles using Mg- and Zn-TMP bases

Figure presented The strong directing ability of the N,N,N′,N′- tetramethyldiaminophosphorodiamidate group has been used to achieve selective metalations on various heterocycles such as pyridines, quinolines and quinoxalines with TMP-derived bases like TMPMgCl·LiCl, TMP 2Mg·2LiCl, and TMP2Zn·2MgCl 2·2LiCl. This protocol was applied in the synthesis of etoricoxib, talnetant and a P-selectin inhibitor.