1224702-79-7Relevant articles and documents
Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities
Kamal, Ahmed,Kumar, B. Ashwini,Suresh, Paidakula,Agrawal, Satyam Kumar,Chashoo, Gousia,Singh, Shashank K.,Saxena
, p. 8493 - 8500 (2010)
A new class of 4β-N-polyaromatic substituted podophyllotoxin congeners have been synthesized and evaluated for their DNA topoisomerase-II (topo-II) inhibition as well as anticancer potential in some human cancer cell lines. The ease of synthesis and inter
NOVEL 4β-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF
-
Page/Page column 11, (2010/06/11)
The present invention provises novel β-amino podophyllotoxin congeners of general formula (A); R = CH3, or H; R1 = (a) or (b) or (c) or (d) or (e) or (f). The present invention also provides a process for the preparation of 4β-amino podophyllotoxin congeners useful as antitumour agents.