122488-90-8 Usage
Purine Derivative
It belongs to the purine class of compounds, featuring a purine ring structure.
Functional Groups
Chlorine Atom (Cl) at the 6 position
Trifluoromethyl Group (-CF?) at the 2 position
4-Methoxy-3-methyl-benzyl Group at the 9 position
Pharmaceutical Applications
Antineoplastic Potential: Research indicates it may inhibit the growth of certain cancer cells.
Antiviral Activity: Shown to have activity against viruses such as Zika and hepatitis C.
Anti-inflammatory and Analgesic Properties: Demonstrated potential as an anti-inflammatory and analgesic agent.
Potential for Medicinal Chemistry
Its diverse pharmacological properties make it a promising candidate for further development and study in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 122488-90-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,4,8 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 122488-90:
(8*1)+(7*2)+(6*2)+(5*4)+(4*8)+(3*8)+(2*9)+(1*0)=128
128 % 10 = 8
So 122488-90-8 is a valid CAS Registry Number.
122488-90-8Relevant articles and documents
Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines
Kelley,Linn,Selway
, p. 1757 - 1763 (2007/10/02)
A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.
