1224886-42-3

Basic information

• Product Name: C₃₅H₄₆N₂O₇
• Synonyms: C₃₅H₄₆N₂O₇
• CAS NO: 1224886-42-3
• Molecular Weight: 606.759
• Mol File: 1224886-42-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₄₆N₂O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₄₆N₂O₇(1224886-42-3)
• EPA Substance Registry System: C₃₅H₄₆N₂O₇(1224886-42-3)

Safety Data

• Hazardous Substances Data: 1224886-42-3(Hazardous Substances Data)

Upstream product

• 1224886-41-2 C₄₁H₅₄N₂O₁₃ 

Downstream Products

• 41833-13-0 4-hydroxymethyl-2-nitrophenol 
• 4449-51-8 cyclopamine 

Relevant articles and documents

Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma

The first glucuronide prodrug of the hedgehog signaling inhibitor cyclopamine was synthesized. The carbamoyl derivatisation of cyclopamine significantly decreased its toxicity towards the U87 human glioblastoma cell line. However, when the prodrug was incubated with β-glucuronidase in the culture media, the active drug was efficiently released thereby restoring its anti-proliferative activity.