1225057-22-6Relevant articles and documents
DDQ-promoted direct C5-alkylation of oxazoles with alkylboronic acids: Via palladium-catalysed C-H bond activation
Lei, Bowen,Wang, Xiaojiao,Ma, Lifang,Jiao, Huixuan,Zhu, Lisi,Li, Ziyuan
, p. 6084 - 6088 (2017)
A novel and concise C5-alkylation of oxazoles using alkylboronic acids as alkyl donors via Pd(ii)-catalysed C-H bond activation has been achieved in moderate to good yields with satisfactory functional group tolerance. Instead of commonly used BQ as a key promoter, DDQ was discovered to be a better additive that significantly promoted this alkylation. This efficient and advanced method represents the first C(sp2)-C(sp3) cross-coupling reaction at the C5-position of oxazoles, which is particularly attractive due to its potential applications in the late-stage functionalization of oxazole-containing bioactive molecules.
Metal-free, organocatalytic cascade formation of C-N and C-O bonds through dual sp3 C-H activation: Oxidative synthesis of oxazole derivatives
Xie, Jin,Jiang, Honglai,Cheng, Yixiang,Zhu, Chengjian
supporting information; experimental part, p. 979 - 981 (2012/02/04)
An organocatalytic cascade reaction that involves the formation of C-N, C-O and CN bonds in one process via dual sp3 C-H activation has been developed. This protocol affords a facile metal-free methodology for the synthesis of oxazole derivatives in air under mild conditions.
