1225384-38-2

Basic information

• Product Name: benzyl ((1s,3R,4S)-3,4-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)cyclopentyl)(methyl)carbamate
• Synonyms: benzyl ((1s,3R,4S)-3,4-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)cyclopentyl)(methyl)carbamate
• CAS NO: 1225384-38-2
• Molecular Weight: 762.213
• Mol File: 1225384-38-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl ((1s,3R,4S)-3,4-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)cyclopentyl)(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl ((1s,3R,4S)-3,4-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)cyclopentyl)(methyl)carbamate(1225384-38-2)
• EPA Substance Registry System: benzyl ((1s,3R,4S)-3,4-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)cyclopentyl)(methyl)carbamate(1225384-38-2)

Safety Data

• Hazardous Substances Data: 1225384-38-2(Hazardous Substances Data)

Upstream product

• 51154-39-3 (9Z,12Z)-octadeca-9,12-dienyl methanesulfonate 
• 1225384-36-0 benzyl (1S,3R,4S)-3,4-dihydroxycyclopentyl(methyl)carbamate 

Relevant articles and documents

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Special (lipid) delivery: The role of the ionizable lipid pKa in the in?vivo delivery of siRNA by lipid nanoparticles has been studied with a large number of head group modifications to the lipids. A tight correlation between the lipid pKa?value and silencing of the mouse FVII gene (FVII ED50) was found, with an optimal pKa range of 6.2-6.5 (see graph). The most potent cationic lipid from this study has ED50 levels around 0.005?mg?kg?1 in mice and less than 0.03?mg?kg?1 in non-human primates.