1225785-23-8Relevant articles and documents
Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
Fullam, Elizabeth,Talbot, James,Abuhammed, Areej,Westwood, Isaac,Davies, Stephen G.,Russell, Angela J.,Sim, Edith
supporting information, p. 2759 - 2764 (2013/06/27)
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis.