122590-88-9Relevant articles and documents
Decarboxylative nucleophilic difluoromethylation of aldehydes and imines
Chen, Jia,Lin, Jin-Hong,Xiao, Ji-Chang
, p. 4295 - 4297 (2018/07/13)
The high demand for the biologically active CF2H-molecules has stimulated significant efforts to develop efficient methods for the installation of CF2H functionality. We found that phenylsulfonyl difluoroacetate salt (PhSO2/sub
Nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls with PhSO2CF2H reagent in the presence of in situ generated substoichiometric amount of base Dedicated to Professor Iwao Ojima on the occasion of his receipt of the ACS Aw
Hu, Mingyou,Gao, Bing,Ni, Chuanfa,Zhang, Laijun,Hu, Jinbo
, p. 52 - 58 (2013/10/01)
The reactions between carbonyl compounds and PhSO2CF 2H using substoichiometric amount of base in situ generated from N(TMS)3 and catalytic amount of Me4NF have been investigated. It is found that both enolizabl
Process for nucleophilic fluoroalkylation of aldehydes
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, (2008/06/13)
Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.