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1226548-19-1

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1226548-19-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1226548-19-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,6,5,4 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1226548-19:
(9*1)+(8*2)+(7*2)+(6*6)+(5*5)+(4*4)+(3*8)+(2*1)+(1*9)=151
151 % 10 = 1
So 1226548-19-1 is a valid CAS Registry Number.

1226548-19-1Relevant articles and documents

PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy

Makino, Akira,Miyazaki, Anna,Tomoike, Ayaka,Kimura, Hiroyuki,Arimitsu, Kenji,Hirata, Masahiko,Ohmomo, Yoshiro,Nishii, Ryuichi,Okazawa, Hidehiko,Kiyono, Yasushi,Ono, Masahiro,Saji, Hideo

supporting information, p. 1609 - 1613 (2018/02/28)

Tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR-TKIs) are used as molecular targeted therapy for non-small cell lung cancer (NSCLC) patients. The therapy is applied to the patients having EGFR-primary L858R mutation, but drug toleran

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: The role of side chain chirality and michael acceptor group for maximal potency

Wu, Chia-Hsien,Coumar, Mohane Selvaraj,Chu, Chang-Ying,Lin, Wen-Hsing,Chen, Yi-Rong,Chen, Chiung-Tong,Shiao, Hui-Yi,Rafi, Shaik,Wang, Sing-Yi,Hsu, Hui,Chen, Chun-Hwa,Chang, Chun-Yu,Chang, Teng-Yuan,Lien, Tzu-Wen,Fang, Ming-Yu,Yeh, Kai-Chia,Chen, Ching-Ping,Yeh, Teng-Kuang,Hsieh, Su-Huei,Hsu, John T.-A.,Liao, Chun-Chen,Chao, Yu-Sheng,Hsieh, Hsing-Pang

experimental part, p. 7316 - 7326 (2011/02/23)

HTS hit 7 was modified through hybrid design strategy to introduce a chiral side chain followed by introduction of Michael acceptor group to obtain potent EGFR kinase inhibitors 11 and 19. Both 11 and 19 showed over 3 orders of magnitude enhanced HCC827 a

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