1226810-19-0Relevant articles and documents
Stilbene analogs as inducers of apolipoprotein-I transcription
Hansen, Henrik C.,Chiacchia, Fabrizio S.,Patel, Reena,Wong, Norman C.W.,Khlebnikov, Vladimir,Jankowska, Renata,Patel, Kalpesh,Reddy, M. Madhava
experimental part, p. 2018 - 2023 (2010/06/19)
Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4′-Dihydroxy-2-methoxystilbene was the most potent (4.6× more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis.
