1227262-26-1Relevant articles and documents
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus
Lee, Kyungae,Campbell, Jennifer,Swoboda, Jonathan G.,Cuny, Gregory D.,Walker, Suzanne
supporting information; experimental part, p. 1767 - 1770 (2010/07/08)
A small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic.