1227465-79-3 Usage
Description
7-fluoro-2-hydroxyquinoline-4-carboxylic acid (SALTDATA: FREE) is a chemical compound with the molecular formula C10H6FNO3. It is a derivative of quinoline and contains a fluorine atom, a hydroxyl group, and a carboxylic acid moiety. This unique structure and functional groups make it a versatile building block for various chemical processes and applications.
Uses
Used in Pharmaceutical Research and Drug Synthesis:
7-fluoro-2-hydroxyquinoline-4-carboxylic acid (SALTDATA: FREE) is used as a pharmaceutical intermediate for the development of new drugs. Its potential therapeutic properties make it a promising candidate for the treatment of various diseases.
Used in Agrochemicals Manufacturing:
7-fluoro-2-hydroxyquinoline-4-carboxylic acid (SALTDATA: FREE) is used as a key component in the production of agrochemicals. Its unique structure and functional groups contribute to the effectiveness of these chemicals in agricultural applications.
Used in Specialty Chemicals Production:
7-fluoro-2-hydroxyquinoline-4-carboxylic acid (SALTDATA: FREE) is also used in the manufacturing of specialty chemicals. Its versatility and unique properties make it a valuable building block for the development of various chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 1227465-79-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,4,6 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1227465-79:
(9*1)+(8*2)+(7*2)+(6*7)+(5*4)+(4*6)+(3*5)+(2*7)+(1*9)=163
163 % 10 = 3
So 1227465-79-3 is a valid CAS Registry Number.
1227465-79-3Relevant articles and documents
Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinoma
Shahin, Mai I.,Roy, Joyeeta,Hanafi, Maha,Wang, Dongyao,Luesakul, Urarika,Chai, Yifeng,Muangsin, Nongnuj,Lasheen, Deena S.,Abou El Ella, Dalal A.,Abouzid, Khaled A.,Neamati, Nouri
, p. 516 - 530 (2018)
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines. Some of the active analogues with IC50 values around 10 μM were tested in three additional cell lines. Our structure-activity relationships revealed remarkable alterations in the anti proliferative activities upon modest chemical modifications and autophagy modulation is a suggested mechanism of action.