1227626-51-8

Basic information

• Product Name: Trityl olMesartan MedoxoMil iMpurity III
• Synonyms: Trityl olMesartan MedoxoMil iMpurity III;(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(prop-1-en-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate;Olmesartan Medoxomil Impurity F
• CAS NO: 1227626-51-8
• Molecular Formula: C₄₈H₄₂N₆O₅
• Molecular Weight: 243.3224
• Mol File: 1227626-51-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 935.7±75.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: 3.86±0.60(Predicted)
• CAS DataBase Reference: Trityl olMesartan MedoxoMil iMpurity III(CAS DataBase Reference)
• NIST Chemistry Reference: Trityl olMesartan MedoxoMil iMpurity III(1227626-51-8)
• EPA Substance Registry System: Trityl olMesartan MedoxoMil iMpurity III(1227626-51-8)

Safety Data

• Hazardous Substances Data: 1227626-51-8(Hazardous Substances Data)

Usage

Description

Trityl olMesartan MedoxoMil iMpurity III is an analog of Olmesartan Medoxomil, which is an angiotensin II receptor antagonist. It is a pharmaceutical compound derived from the Olmesartan Medoxomil family and is characterized by its trityl group and the absence of the 4-hydroxy group.

Uses

Used in Pharmaceutical Industry:
Trityl olMesartan MedoxoMil iMpurity III is used as a pharmaceutical compound for the development of treatments targeting angiotensin II receptor antagonists. Its role in this application is to potentially provide alternative or improved therapies for conditions such as hypertension and heart failure, where angiotensin II receptor antagonists are commonly utilized.
Additionally, as an analog of Olmesartan Medoxomil, Trityl olMesartan MedoxoMil iMpurity III may be used in research and development for understanding the structure-activity relationships of angiotensin II receptor antagonists, which could lead to the discovery of new and more effective drugs in this class.

Upstream product

• 144690-92-6 trityl olmesartan medoxomil 

Downstream Products

• 879562-26-2 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl1-((2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl)-4-(prop-1-en-2-yl)-2-propyl-1H-imidazole-5-carboxylate 

Relevant articles and documents

Synthesis of related substances of olmesartan medoxomil, antihypertensive drug

Olmesartan medoxomil 1 is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, four related substances (impurities) were observed along with the final API