122772-04-7

Basic information

• Product Name: 1-(3,4-dimethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide
• Synonyms: 1-(3,4-dimethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide
• CAS NO: 122772-04-7
• Molecular Weight: 361.422
• Mol File: 122772-04-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dimethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide(122772-04-7)
• EPA Substance Registry System: 1-(3,4-dimethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide(122772-04-7)

Safety Data

• Hazardous Substances Data: 122772-04-7(Hazardous Substances Data)

Upstream product

• 41764-74-3 3,4-dimethoxybenzohydrazide 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 93-07-2 Veratric acid 
• 104-94-9 4-methoxy-aniline 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 

Downstream Products

• 1403569-04-9 C₁₇H₁₇N₃O₃S 
• 122772-23-0 5-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-2,4-dihydro-1,2,4-triazole-3-thione 
• 1407152-65-1 C₁₇H₁₇N₃O₄ 
• 122772-23-0 5-(3,4-Dimethoxy-phenyl)-4-(4-methoxy-phenyl)-4H-[1,2,4]triazole-3-thiol 

Relevant articles and documents

Synthesis, urease and acetylcholine esterase inhibition activities of some 1,4-disubstituted thiosemicarbazides and their 2,5-disubstituted thiadiazoles

A new series of 2,5-disubstituted-1,3,4-thiadiazoles 6a-i was synthesized by overnight stirring various 1,4-disubstituted thiosemicarbazides 5a-i in polyphosphoric acid followed by neutralization. The structures of newly synthesized compounds 5a-i and 6a-i were characterized by IR, 1H and 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were evaluated for their urease and acetylcholine esterase inhibition activities. Thiosemicarbazides 5a-i are found to possess excellent potential for urease inhibition, more than the standard drug. Thiosemicarbazides 5a-i are more potent urease inhibitor than their cyclic analogues thiadiazoles 6a-i. Almost all of the compounds are excellent inhibitors of acetylcholine esterase. The inhibition of acetylcholine esterase of compounds 5a, 5c, 5d, 5g, 5i, 6e, 6f, 6g, and 6i is much more than that of standard drug.

Synthesis of 5-aryl-3-mercapto-4-substituted-triazoles

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