122778-03-4

Basic information

• Product Name: C-<4-(α,α,α-trifluoromethyl)phenyl>-N-tert-butylnitrone
• CAS NO: 122778-03-4
• Molecular Weight: 245.244
• Mol File: 122778-03-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: C-<4-(α,α,α-trifluoromethyl)phenyl>-N-tert-butylnitrone(CAS DataBase Reference)
• NIST Chemistry Reference: C-<4-(α,α,α-trifluoromethyl)phenyl>-N-tert-butylnitrone(122778-03-4)
• EPA Substance Registry System: C-<4-(α,α,α-trifluoromethyl)phenyl>-N-tert-butylnitrone(122778-03-4)

Safety Data

• Hazardous Substances Data: 122778-03-4(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 594-70-7 2-Methyl-2-nitropropane 
• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 125640-88-2 tert-Butyl<(4-trifluoromethyl)benzyl>amine 

Downstream Products

• 1353012-94-8 (3S,5S)-5-methyl-3-(4-trifluoromethylphenyl)-2-tert-butylisoxazolidine-5-carbaldehyde 

Relevant articles and documents

Iridium-Catalyzed Direct C-H Sulfamidation of Aryl Nitrones with Sulfonyl Azides at Room Temperature

Ir(III)-catalyzed direct C-H sulfamidation of aryl nitrones has been developed to synthesize various sulfamidated nitrones in moderate to excellent yields with excellent regioselectivity and broad functional group tolerance. This transformation could proceed smoothly at room temperature with low catalyst loading in the absence of external oxidants, acids, or bases. Molecular nitrogen was released as the sole byproduct, thus providing an environmentally benign sulfamidation process. And this protocol could efficiently apply to synthesize the substituted benzisoxazoline via one-step transformation from the product.

Activation of C-H bonds in nitrones leads to iridium hydrides with antitumor activity

We report the design and synthesis of a series of new cyclometalated iridium hydrides derived from the C-H bond activation of aromatic nitrones and the biological evaluation of these iridium hydrides as antitumor agents. The nitrone ligands are based on the structure of a popular antioxidant, α-phenyl-N-tert-butylnitrone (PBN). Compared to cisplatin, the iridium hydrides exhibit excellent antitumor activity on HepG2 cells. The metal-coordinated compound with the most potent anticancer activity, 2f, was selected for further analysis because of its ability to induce apoptosis and interact with DNA. During in vitro studies and in vivo efficacy analysis with tumor xenograft models in Institute of Cancer Research (ICR) mice, complex 2f exhibited antitumor activity that was markedly superior to that of cisplatin. Our results suggest, for the first time, that metal hydrides could be a new type of metal-based antitumor agent.

COMPOSITIONS AND METHODS OF INHIBITING RETINAL DEGENERATION

Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compos