1227796-84-0

Basic information

• Product Name: (4-chlorophenyl)(pyrrolo[2,1-a]isoquinolin-3-yl)methanone
• Synonyms: (4-chlorophenyl)(pyrrolo[2,1-a]isoquinolin-3-yl)methanone
• CAS NO: 1227796-84-0
• Molecular Weight: 305.763
• Mol File: 1227796-84-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-chlorophenyl)(pyrrolo[2,1-a]isoquinolin-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)(pyrrolo[2,1-a]isoquinolin-3-yl)methanone(1227796-84-0)
• EPA Substance Registry System: (4-chlorophenyl)(pyrrolo[2,1-a]isoquinolin-3-yl)methanone(1227796-84-0)

Safety Data

• Hazardous Substances Data: 1227796-84-0(Hazardous Substances Data)

Upstream product

• 57269-96-2 2-(2-(4-chlorophenyl)-2-oxoethyl)isoquinolin-2-ium bromide 
• 215438-84-9 methyl diphenylsulfonium triflate 
• 108-31-6 maleic anhydride 

Relevant articles and documents

One-pot synthesis of pyrrolo[2,1-a]isoquinolines via tandem reactions of vinylselenonium salt, 2-bromoethanones, and isoquinoline

An convenient and one-pot synthesis of pyrrolo[2,1-a]isoquinolines via the tandem reaction of methyl(phenyl)vinylselenonium salt with isoquinoline and 2-bromoethanones has been developed, which features very mild conditions, available substrates, simple experimental procedures, moderate to good yields, and wide functional group tolerance.

Regioselective synthesis of 3-acylindolizines and benzo- analogues via 1,3-dipolar cycloadditions of N-ylides with maleic anhydride

3-Acylindolizines (5a-5f) and their benzo- analogues 1-acylpyrrolo[1,2-a] quinolines (6a-6f) and 1-acylpyrrolo[2,1-a]isoquinolines (7a-7i) are regioselectively synthesized by a convenient one pot reaction of the corresponding pyridinium (quinolinium, isoquinolinium) ylide with maleic anhydride (MA) in the presence of the mild oxidant tetrakispyridinecobalt(ii) dichromate (TPCD). These reactions proceed via a tandem reaction sequence of 1,3-dipolar cycloaddition of azomethine ylide with MA, anhydride hydrolysis and oxidative bisdecarboxylation of the primary cycloadducts followed by dehydrogenative aromatization of the dihydroindolizines. TPCD serves as both decarboxylation and dehydrogenation reagent in the reactions. These results show that TPCD is a promising new reagent for bisdecarboxylation of aliphatic carboxylates.