1227851-94-6

Basic information

• Product Name: 3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol
• CAS NO: 1227851-94-6
• Molecular Weight: 329.422
• Mol File: 1227851-94-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol(1227851-94-6)
• EPA Substance Registry System: 3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol(1227851-94-6)

Safety Data

• Hazardous Substances Data: 1227851-94-6(Hazardous Substances Data)

Upstream product

• 81226-95-1 1-phenyl-3-(3-hydroxyphenyl)-2-propen-1-one 
• 7465-65-8 1-[2-oxo-2-(thiophen-2-yl)ethyl]pyridinium iodide 

Relevant articles and documents

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Structure-activity relationship study revealed that the substitution of hydroxyl group(s) increased topoisomerase I and II inhibitory activity in the order of meta > para > ortho position. Substitution of hydroxyl group on the para position showed better cytotoxicity.