1228439-40-4Relevant articles and documents
Benzyl prolinate derivatives as novel selective KCC2 blockers
Pégurier, Cécile,Bosman, Nathalie,Collart, Philippe,Delporte, Marie-Laure,Leclercq, Karine,Lengelé, Sébastien,Kanduluru, Ananda Kumar,Meunier, Stéphane,Pacico, Nathalie,Vadali, Lakshmana Rao,Wagner, Alain,Wolff, Christian,Provins, Laurent
scheme or table, p. 2542 - 2545 (2010/07/04)
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R1 phenyl group im