1228632-20-9

Basic information

• Product Name: [(2R)-4,4-dimethylpentan-2-yl]benzene
• Synonyms: [(2R)-4,4-dimethylpentan-2-yl]benzene
• CAS NO: 1228632-20-9
• Molecular Weight: 176.302
• Mol File: 1228632-20-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [(2R)-4,4-dimethylpentan-2-yl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R)-4,4-dimethylpentan-2-yl]benzene(1228632-20-9)
• EPA Substance Registry System: [(2R)-4,4-dimethylpentan-2-yl]benzene(1228632-20-9)

Safety Data

• Hazardous Substances Data: 1228632-20-9(Hazardous Substances Data)

Upstream product

• 7283-47-8 (4,4-dimethylpent-1-en-2-yl)benzene 

Relevant articles and documents

Extending the substrate scope of bicyclic p-oxazoline/thiazole ligands for ir-catalyzed hydrogenation of unfunctionalized olefins by introducing a biaryl phosphoroamidite group

This study identifies a series of Ir-bicyclic phosphoroamidite-oxazoline/thiazole catalytic systems that can hydrogenate a wide range of minimally functionalized olefins (including E- and Z-tri- and disubstituted substrates, vinylsilanes, enol phosphinates, tri- and disubstituted alkenylboronic esters, and ?±,?2-unsaturated enones) in high enantioselectivities (ee values up to 99%) and conversions. The design of the new phosphoroamidite-oxazoline/thiazole ligands derives from a previous successful generation of bicyclic N-phosphane-oxazoline/thiazole ligands, by replacing the N-phosphane group with a p-acceptor biaryl phosphoroamidite moiety. A small but structurally important family of Ir-phosphoroamidite-oxazoline/thiazole precatalysts has thus been synthesized by changing the nature of the Ndonor group (either oxazoline or thiazole) and the configuration at the biaryl phosphoroamidite moiety. The substitution of the N-phosphane by a phosphoroamidite group in the bicyclic N-phosphane-oxazoline/thiazole ligands extended the range of olefins that can be successfully hydrogenated.

A modular furanoside thioether-phosphite/phosphinite/ phosphine ligand library for asymmetric iridium-catalyzed hydrogenation of minimally functionalized olefins: Scope and limitations

A highly modular furanoside thioether-phosphite/phosphinite/phosphine ligand library has been synthesized for the iridium-catalyzed asymmetric hydrogenation of minimally functionalized olefins. These ligands can be prepared efficiently from easily accessible D-(+)-xylose. We found that their effectiveness at transferring the chiral information in the product can be tuned by correctly choosing the ligand components. Enantioselectivities were therefore excellent (ees up to 99%) in a wide range of E- and Z-trisubstituted alkenes using 5-deoxyribofuranoside thioether-phosphite ligands. It should be pointed out that these catalysts are also very tolerant to the presence of a neighbouring polar group. For 1,1-disubstituted substrates, both enantiomers of the hydrogenation product can be obtained in high enantioselectivities simply by changing the configuration of the biaryl phosphite moiety. The asymmetric hydrogenation was also performed using propylene carbonate as solvent, which allowed the iridium catalysts to be reused while maintaining the excellent enantioselectivities. Copyright

Iridium-catalyzed asymmetric hydrogenation of olefins using TIQ phosphine-oxazoline ligands

A novel family of tetrahydroisoquinoline (TIQ) phosphine-oxazoline ligands and four corresponding iridium complexes have been developed and applied to the asymmetric hydrogenation of unfunctionalized olefins. The results showed that the best conversion rates were observed in up to 99% with an enantiomeric excess of 91%.