1228652-31-0Relevant articles and documents
Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 antagonist as a development candidate
Zhang, Xuqing,Hou, Cuifen,Hufnagel, Heather,Singer, Monica,Opas, Evan,McKenney, Sandra,Johnson, Dana,Sui, Zhihua
, p. 1039 - 1044 (2013/02/23)
We have discovered a novel series of 4-Azetidinyl-1-Aryl-cyclohexanes as CCR2 antagonists. Divergent SAR studies on hCCR2 and hERG activities led to the discovery of compound 8d, which displayed good hCCR2 binding affinity (IC 50, 37 nM) and po