1228680-89-4

Basic information

• Product Name: 3-Bromobenzyl-acetohydroxamic acid
• Synonyms: 3-Bromobenzyl-acetohydroxamic acid
• CAS NO: 1228680-89-4
• Molecular Weight: 244.088
• Mol File: 1228680-89-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Bromobenzyl-acetohydroxamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromobenzyl-acetohydroxamic acid(1228680-89-4)
• EPA Substance Registry System: 3-Bromobenzyl-acetohydroxamic acid(1228680-89-4)

Safety Data

• Hazardous Substances Data: 1228680-89-4(Hazardous Substances Data)

Upstream product

• 335159-82-5 3-(m-bromophenyl)propionyl chloride 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 
• 52739-46-5 E-3-bromo-benzaldehyde-oxime 
• 497-19-8 sodium carbonate 

Downstream Products

• 67805-68-9 8-bromo-3,4-dihydroquinolin-2(1H)-one 
• 3279-90-1 6-bromo-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

SUBSTITUTED PHENYLACETYLENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS AND COMPOSITIONS

Substituted phenylacetylenes of the formula STR1 wherein one of the groups R1 is a hydrogen atom and the other represents the group of the formula STR2 in which R3 is hydrogen, methyl or ethyl and R4 is a methyl or an amino group and wherein R2 represents mono- or binuclear aromatic or heterocyclic residues containing sulfur, nitrogen or oxygen as hetero atoms and optionally being substituted by 1 to 3 substituents as defined, which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The compounds may be prepared by reacting a compound of the formula STR3 wherein R2 has the same meaning as above and one of the groups R7 is a hydrogen atom and the other represents the group of the formula --COR3, with hydroxylamine to form the oxime which then is reduced to the corresponding hydroxylamine compound into which the group of the formula --COR4 is introduced.