1229018-85-2

Basic information

• Product Name: 2-chloro-N-(3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl) acetamide
• Synonyms: 2-chloro-N-(3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl) acetamide
• CAS NO: 1229018-85-2
• Molecular Weight: 377.871
• Mol File: 1229018-85-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl) acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl) acetamide(1229018-85-2)
• EPA Substance Registry System: 2-chloro-N-(3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl) acetamide(1229018-85-2)

Safety Data

• Hazardous Substances Data: 1229018-85-2(Hazardous Substances Data)

Upstream product

• 63874-26-0 2-n-propoxybenzamidine 
• 59643-84-4 2-n-propoxybenzamide 
• 65-45-2 salicylamide 
• 1229017-39-3 2-(5-amino-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone 
• 79-04-9 chloroacetyl chloride 
• 1229017-38-2 2-(5-nitro-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone 
• 1229019-57-1 2-(2-n-Propoxyphenyl)-5,6-diethylpyrimid-4(3H)-one 

Downstream Products

• 1229018-86-3 2-(dimethylamino)-N-(3-(4,5-diethyl-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)acetamide 
• 1229018-87-4 N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide 
• 1229018-89-6 N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)-2-(piperidin-1-yl)acetamide 

Relevant articles and documents

Facile and Cost-Effective Route for the Synthesis of Simmerafil

An improved synthesis of simmerafil, a potent PDE5 inhibitor as a clinical candidate, is described with a 38.1% overall yield and 99.7% purity. Starting from the safe and inexpensive salicylamide (15), the key intermediate 2-propoxybenzimidamide (21), which is also a potential precursor for the preparation of pyrimidinone derivatives, was effectively and conveniently obtained. The subsequent process from21to simmerafil was optimized, which makes it more amenable to scale-up.

PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF

The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following f