1229225-42-6 Usage
Description
(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]methyl]-1-naphthalenemethaneamine hydrochloride, also known as (αR)-α-Methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-1-naphthalenemethanamine, is a chemical compound with a complex structure. It is characterized by its hydrochloride salt form, which contributes to its stability and solubility in aqueous environments. (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]methyl]-1-naphthalenemethaneamine hydrochloride is primarily recognized as a benzylamine impurity associated with Cinacalcet, a drug used for the treatment of secondary hyperparathyroidism.
Uses
Used in Pharmaceutical Industry:
(R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]methyl]-1-naphthalenemethaneamine hydrochloride is used as a benzylamine impurity in the synthesis and production of Cinacalcet (C441800). Its presence is crucial for the development and formulation of Cinacalcet, a calcimimetic agent that helps regulate parathyroid hormone levels in patients with chronic kidney disease undergoing dialysis.
In the pharmaceutical industry, the compound plays a significant role in the manufacturing process of Cinacalcet, ensuring the drug's efficacy and safety. The compound's specific properties, such as its trifluoromethyl and naphthalene groups, contribute to its interaction with the target receptors and its overall contribution to the drug's mechanism of action.
Additionally, the compound may be used in research and development for the discovery of new drugs with similar mechanisms of action or for the improvement of existing drugs in the treatment of secondary hyperparathyroidism and other related conditions. Its unique structure and properties make it a valuable candidate for further investigation and potential application in the pharmaceutical field.
Check Digit Verification of cas no
The CAS Registry Mumber 1229225-42-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,2,2 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1229225-42:
(9*1)+(8*2)+(7*2)+(6*9)+(5*2)+(4*2)+(3*5)+(2*4)+(1*2)=136
136 % 10 = 6
So 1229225-42-6 is a valid CAS Registry Number.
1229225-42-6Relevant articles and documents
HIGHLY PURE CINACALCET OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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Page/Page column 45, (2010/07/02)
Provided herein are impurities of cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl) phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methaneamine (tetrahydro cinacalcet impurity), (R)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1- naphthalenemethaneamine-N-oxide (cinacalcet N-oxide impurity) and (R)-α-methyl-N-[3-[3- (trifiuoromethyl)phenyl]methyl]-1-naphthalenemethaneamine (benzylamine impurity); and processes for preparation and isolation thereof. Provided further herein is a highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities.
