1229404-09-4

Basic information

• Product Name: E-4,4'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol]
• Synonyms: E-4,4'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol]
• CAS NO: 1229404-09-4
• Molecular Weight: 354.492
• Mol File: 1229404-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: E-4,4'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol](CAS DataBase Reference)
• NIST Chemistry Reference: E-4,4'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol](1229404-09-4)
• EPA Substance Registry System: E-4,4'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol](1229404-09-4)

Safety Data

• Hazardous Substances Data: 1229404-09-4(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 13366-36-4 trans-2,3-bis(4-hydroxyphenyl)-2-butene 
• 124-40-3 dimethyl amine 

Relevant articles and documents

Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: Significance of the para-hydroxyl orientation

In this study, we analyzed the structure-activity relationship properties of the small molecule Jak2 inhibitor G6. We synthesized a set of derivatives containing the native para-hydroxyl structure or an alternative meta-hydroxyl structure and examined their Jak2 inhibitory properties. We found that the para-hydroxyl derivative known as NB15 had excellent Jak2 inhibitory properties in silico, in vitro, and ex vivo when compared with meta-hydroxyl derivatives. These results indicate that NB15 is a potent derivative of the Jak2 inhibitor G6, and that maintaining the para-hydroxyl orientation of G6 is critical for its Jak2 inhibitory potential.